J Exp Med. What Is 'Covid Arm,' A Side Effect From Covid-19 Coronavirus Vaccines? Oster ME, Shay DK, Su JR, Gee J, et al. See a study on these cases in the AstraZeneca vaccine in the New England Journal of Medicine here and a report from the British governments regulatory agency here. FDA takes additional action in fight against COVID-19 by issuing emergency use authorization for second COVID-19 vaccine. What Are The Side Effects Of The Coronavirus Vaccine? J&J Vaccine: Side Effects, Guillain-Barr Syndrome and More - NBC Chicago Fernandes A, Chaudhari S, Jamil N, Gopalakrishnan G. Endocr Pract. The type and location of the rashes were not detailed. The baseline rates for myocarditis in those age groups are 1.34 [95% CI, 1.051.72] and 0.42 [95% CI, 0.270.66] cases per million persons, respectively. April 14 is scheduled as a day off for the academic campus to rejuvenate. Greinacher A, Thiele T, Warkentin TE, Weisser K, et al. This paper, along with its companion that covers xenobiotics and alternative remedies, is an update to . The .gov means its official. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 2022. from https://www.fda.gov/media/145802/download. The side effects after the second vaccine dose are likely stronger than after the first dose. Safety and immunotoxicity assessment of immunomodulatory monoclonal antibodies. COVID Vaccine Side Effects | Johns Hopkins Medicine To obtain Any risk is frightening, especially for a parent. Reactions that occurred within 24h of the infusion were considered related to the infusion. A prospective study of the incidence of myocarditis/pericarditis and new onset cardiac symptoms following smallpox and influenza vaccination.PLoS One. COVID-19 Therapeutics: Use, Mechanism of Action, and Toxicity (Vaccines Up to 10 percent of people who have COVID experience side effects" such as difficulty thinking, pain, tiredness, loss of taste and depression. An open, non-randomised, phase 1/2 trial on the safety, tolerability, and immunogenicity of single-dose vaccine Sputnik Light for prevention of coronavirus infection in healthy adults. SCB-2019 is a recombinant protein vaccine that contains antigenic subunits of the S protein with adjuvants AS03 (-tocopherol, squalene and polysorbate 80 in an oil-in-water emulsion) or CpG/Alum (a toll-like receptor agonist complexed with aluminum). https://doi.org/10.1542/peds.2021-052478. In a new research letter, published in the journal JAMA Dermatology, physicians from Madrid reported on a small group of patients with confirmed coronavirus who had "enanthem," or lesions inside their mouth. Agresti N, Lalezari JP, Amodeo PP, Mody K, et al. Springer Nature or its licensor (e.g. COVID-19 vaccine safety and side effects One patient had anaphylaxis. Nakazawa F, Kannemeier C, Shibamiya A, Song Y, et al. Part of Springer Nature. We only considered peer-reviewed publications for which the full-text in English was available. In addition to the genetic material, the other ingredients of the COVID-19 vaccine support the mRNA and allow it to be delivered into cells. An interim analysis of an ongoing double-blinded multicenter trial, COMET-ICE, found that non-hospitalized patients with COVID-19 who received a one-time infusion of 500mg sotrovimab were 85% relatively less likely (6% absolute risk reduction) to be hospitalized due to disease progression in the 29days following the infusion than those who received saline [16]. A: COVID-19 vaccines can cause mild side effects, such as pain, redness or swelling where the shot was given, fever, fatigue, headache, chills and muscle or joint pain. This is particularly true of the mRNA vaccines. Up to 10 percent of people who have COVIDexperience side effectssuch as difficulty thinking, pain, tiredness, loss of taste and depression. Understanding COVID-19 vaccine side effects, why second dose could feel Taking OTC pain medications ahead of your shot to try and decrease symptoms is not recommended by the CDC, because it's not clear how that could affect the vaccine's effectiveness. Mevorach D, Anis E, Cedar N, Bromberg M, et al. https://www.fda.gov/media/149534/download. Side Effects of COVID-19 Vaccines - World Health Organization Before Ad26 elicits a less robust T cell response than Ad5 [109] but escapes immunity to Ad5 [110]. 2021 Jun 26;13(6):e15935. A person might also experience side effects around the injection site, which is usually the upper arm. https://doi.org/10.1016/S0140-6736(21)00241-5. Yang B, Fulcher JA, Ahn J, Berro M, et al. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. That is not to say that there have never been safety issues with vaccines. Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 1859 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial. RECOVERY Collaborative Group. Pekosz advises people who are worried about feeling down for a day or two after getting a booster to try to schedule it when they have a couple of days off from work. There were no life-threatening reactions. Breedveld FC. Although adverse events may occur after being vaccinated with a COVID-19 vaccine, they are not necessarily related to the vaccine. Most people also need a booster dose to help improve the protection from the first 2 doses of the vaccine. The BLAZE-1 clinical trial also evaluated the combination of bamlanivimab and etesevimab, which did reduce viral load. We included substances we did not previously discuss, choosing based on the vaccines being recommended by the Center for Disease Control and our experience as practicing physicians and scientists. 2016;64(6):140315. An earlier COVID-19 infection, but not what's known as. Michael A. Chary is supported by the Loan Repayment Program (National Institute for Drug Abuse, National Institutes of Health). COVID-19: Vaccine side effects and reactions - Ministry of Health NZ (Photo by: Andrea Mabry) In his nearly 30 years studying vaccines, Paul Goepfert, M.D., director of the Alabama Vaccine Research Clinic at theUniversity of Alabama at Birmingham, has never seen any vaccine as effective as the three COVID vaccines from Pfizer, Moderna, and Johnson & Johnson currently available in the United States. JAMA. Oral side effects of COVID-19 vaccine Br Dent J. Available at: https://stars.library.ucf.edu/cgi/viewcontent.cgi?article=1306&context=honorstheses (accessed December 2020). Side effects from the second shot tend to be worse than the first. Fewer than 6% of patients experienced nausea or diarrhea, which were comparable to placebo groups. UAB - The University of Alabama at Birmingham, survey of parents with children ages 12-15, vaccines are still protective against Delta, 2023 The University of Alabama at Birmingham. Hence, the aim of this study was to compare the orofacial adverse effects of two recently authorised COVID-19 vaccines, namely BNT162b2 and mRNA-1273. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. https://doi.org/10.1056/NEJMoa2109730. Correspondence to seeing spots or floaters vision loss What are most common side effects from COVID-19 vaccines? Chary MA, Barbuto AF, Izadmehr S, Hayes BD, Burns MM. This differs from the initially authorized dose of 1200mg of casirivimab and 1200mg of imdevimab, reflecting a phase 3 study that showed similar efficacy at the lower dose. White spots on your tongue can be a sign of Covid or a vaccine side An equal amino acid substitution is one that exchanges one amino acid for another biochemically similar one. Accessed 22 Mar 2022, National Center for Immunization and Respiratory Diseases (U.S.).Division of Viral Diseases, Moderna COVID-19 Vaccine (also known as Spikevax) Overview and Safety. Drinking lots of fluids is wise if you're feverish, and wearing lightweight clothing can also keep you comfortable. Epub 2021 Sep 4. Case series report that self-limited chills and fevers are the main adverse events [9]. Vaccines, given in one- or two-shot doses, are very different from medicines that people take every day, potentially for years, Goepfert says. Research on children has shown that those who take acetaminophen before getting vaccines have a lower immune response than those who didn't. This study included patients 18years or older whose symptoms began within the last 5days with at least 1 risk factor for disease progression (2). https://doi.org/10.1148/radiol.2021211766. https://doi.org/10.1093/cid/ciaa449. Thank you for visiting nature.com. Angela Stowe, Ph.D., director of Student Counseling Services, offers ways to grow your resiliency and make it stronger.. https://doi.org/10.1016/s0140-6736(00)01034-5. None of the COVID vaccines uses a weakened form of the SARS-CoV-2 virus all train the body to recognize a piece of the virus known as the spike protein and generate antibodies that can attack the virus in case of a real infection. https://doi.org/10.1016/j.jacc.2003.11.053. A meta-analysis of 32 studies (29 cohort studies and 3 clinical trials) found no difference in mortality or frequency of adverse events [26]. https://doi.org/10.1073/pnas.0608647104. That is the most troubling unknown for me., Even as cases, hospitalizations and deaths have declined significantly in Alabama since January, there are still nearly 250 new COVID cases diagnosed and nearly 10 deaths reported statewide per day as of mid-June, Many people worry that these vaccines were rushed into use and still do not have full FDA approval they are currently being distributed under Emergency Use Authorizations, Goepfert said. https://doi.org/10.1016/S1473-3099(21)00396-0. J Transl Autoimmun. The increased incidence of myocarditis in young adult men is not unique to mRNA vaccines for COVID. A Vaccine Side Effect Leaves Women Wondering: Why Isn't the Pill Safer? 81.7.11.205 https://doi.org/10.26355/eurrev_202102_24877. https://doi.org/10.1007/s13181-020-00777-5. Side effects might show up within one to three days after vaccination, and could last for one to three days after symptoms start. Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: a preliminary report of a randomized, blinded, placebo-controlled, Phase 2 clinical trial in adults at high risk of viral exposure. Alhandod TA, Rabbani SI, Almuqbil M, Alshehri S, Hussain SA, Alomar NF, Mir MA, Asdaq SMB. What are the long-term side effects of COVID vaccines? 3 things - UAB 2022 Oct;11(10):5879-5886. doi: 10.4103/jfmpc.jfmpc_205_22. Tubes of blood drawn from Brianne Dressen, who suffered complications after a coronavirus vaccine, are part of a National Institutes of Health study. Conclusion: Feeling stuck because of COVID? A review on oral manifestations of COVID-19 disease. None of these ingredients include any coronavirus material at all. Ann Med Health Sci Res 2014; 4: 829. People Are Reporting Unexpected Side Effects After COVID-19 - Time "That is about one in a million, or possibly higher rates in some populations, but again all of these occur no more than a month after the vaccination," Goepfert said. 2020 Dec 1;16(12):3061-3073. doi: 10.1080/21645515.2020.1830683. An abnormal echocardiogram was reported in 39% with 15% having LVEF<50% [77]. Perhaps the antibodies the immune system makes have off-target effects (molecular mimicry). 2021;10(333):51120. Google Scholar. One month later, the FDA issued EUAs for Modernas vaccine and for monoclonal antibodies designed to prevent disease progression in those infected with SARS-CoV-2 with mild symptoms and major comorbidities. mRNA degrades incredibly rapidly. Post-vaccine side effects can include soreness at the site of injection, a low-grade fever, headaches, muscle aches and fatigue, Moss said. 2021;6:99. https://doi.org/10.1038/s41578-021-00281-4. Pfizer and Moderna vaccines increase the risk of myocarditis. Myocarditis following COVID-19 vaccination. Bamlanivimab/etesevimab is given as an IV infusion in 0.9% saline. Advice from five fellow employees on getting started, finding a group, staying motivated and coping with weather. A Systematic Review on the Safety and Efficacy of COVID-19 Vaccines Approved in Saudi Arabia. Non-IgE mediated responses to the lipid or PEG are also possible [93]. An analysis of 50,000 hospitalized patients with COVID who received convalescent plasma through the FDAs Early Access Program reported transfusion reactions (n=78), thromboembolic or thrombotic events (n=113, 75 judged unrelated), and cardiac events (n=677; 597 judged unrelated), mainly myocarditis and acute coronary syndrome [10]. The speed of development and effectiveness of vaccines has been matched by public resistance to receiving the vaccine and misinformation [3], mostly over-emphasizing the adverse effects of the vaccine and downplaying the risks of untreated COVID-19, a calculus that also changes with each variant [4]. Chills, headache, and fatigue after a shot are perfectly normal. In a phase I trial of 130 participants in Wuhan, China, within 7days after vaccination, adverse events occurred in approximately 70% of those who received the vaccine intramuscularly and 65% of those who received it via nebulizer. Iguchi T, Umeda H, Kojima M, Kanno Y, et al. You wouldnt expect any of these vaccines to have any long-term side effects. Many Americans say they want to make sure the shot is safe before getting vaccinated. US case reports of cerebral venous sinus thrombosis with thrombocytopenia after Ad26.COV2.S Vaccination, March 2 to April 21, 2021. Facilitators and barriers to COVID-19 vaccine uptake among women in two regions of Ghana: A qualitative study. We also included each vaccines application for Emergency Use Authorization by the FDA. Hepatitis B vaccination and associated oral manifestations: A non-systematic review of literature and case reports. These might include swelling, pain, redness, an itchy rash, and other mild forms of . Di Spirito F, Amato A, Di Palo MP, Contaldo M, D'Ambrosio F, Lo Giudice R, Amato M. Int J Environ Res Public Health. 2021 John Wiley & Sons A/S. Nurse Shares COVID Vaccine Side Effects from Trial The Pfizer-BioNTech (BNT162b2) and the Moderna (mRNA-1273) vaccines confer passive immunity against SARS-CoV-2 by raising antibodies against the Spike (S) protein. "The side effects that we see occur early on and that's it," Goepfert said. Vok Z, Kiss Z, Surjn G, Surjn O, et al. Convalescent plasma is plasma pooled from those who contracted and then recovered from COVID-19. Immunogenicity of the Ad26.COV2.S vaccine for COVID-19. COVID-19 - Recent advancements in identifying novel vaccine candidates and current status of upcoming SARS-CoV-2 vaccines. In 1976, a vaccine against swine flu that was widely distributed in the United States was identified in rare cases (approximatelyone in 100,000) as a cause of Guillain-Barr Syndrome, in which the immune system attacks the nerves. https://doi.org/10.1128/JVI.02407-10. Those individuals should continue as normal, but check with their doctor for additional guidance before getting the vaccine, as there could be ramifications for skipping medication. CAS But what makes vaccine experts such as Goepfert confident that COVID vaccines are safe in the long term? 2014;355(3):63545. The https:// ensures that you are connecting to the Those who received the vaccine reported more adverse events than those who received the placebo, usually lymphadenopathy in the arm and neck. And decades of vaccine history plus data from more than a billion people who have received COVID vaccines starting last December provide powerful proof that there is little chance that any new dangers will emerge from COVID vaccines. Pfizer and Moderna and later Johnson & Johnson and then Novavax, which reported on its Phase III trial results in June 2021 "all have enrolled 30,000-plus individuals, half of whom got the vaccine and half of whom got a placebo initially, after which all the placebo group got the vaccine," Goepfert said. The most commonly reported side effects were: Fever Headache Fatigue (tiredness) Pain at the injection site Helpful tips to relieve side effects Adults To relieve pain or swelling on the arm where you got the shot: Apply a clean, cool, wet washcloth over the area. Fischer S, Gerriets T, Wessels C, Walberer M, et al. National Center for Immunization and Respiratory Diseases (U.S.).Division of Viral Diseases. 2021 May 7;18(9):4965. doi: 10.3390/ijerph18094965. Of the 54,082 individual reports, 518 were following a bivalent vaccine. Monoclonal antibodies and convalescent plasma have similar infusion-related reactions. LNPs, originally designed to ferry xenobiotics, allow the mRNA to infect (enter) the cell, which it cannot do on its own. After DNA vaccines, those aged 3050 are very slightly more likely to have thrombotic disease. The most common side effects . Here we provide a narrative review of the biologic therapeutics used or proposed to treat COVID-19 during the last 3 years. https://doi.org/10.4110/in.2015.15.2.51. 2007;110(7):245765. DNA vaccines introduce viral DNA into host cells that codes for a protein or proteins integral to viral function (for SARS-CoV-2 usually the S protein). Safety and immunogenicity of S-Trimer (SCB-2019), a protein subunit vaccine candidate for COVID-19 in healthy adults: a phase 1, randomised, double-blind, placebo-controlled trial. 2021 Oct;111:310-312. doi: 10.1016/j.ijid.2021.08.071. BNT162b2; Bell's palsy; COVID-19; Vaccine; mRNA-1273; side effects. COVID-19 vaccines: comparison of biological, pharmacological characteristics and adverse effects of Pfizer/BioNTech and Moderna Vaccines. In our previous publication we discussed the recombinant protein APN01, humanized antibody leronlimab, nucleotide analogs remdesivir and favipiravir, protease inhibitors lopinavir/ritonavir, DNA vaccines (S-trimer, INO-4800, GLS-5300), the Moderna mRNA vaccine, and convalescent plasma [5]. 2022 Jan;22(1):64-72. doi: 10.1016/S1473-3099(21)00451-5. Oral Lesions Following Anti-SARS-CoV-2 Vaccination: A Systematic Review. Disruption of CCR5 signaling to treat COVID-19-associated cytokine storm: case series of four critically ill patients treated with leronlimab. The following outcomes were selected and defined by the authors based on information from regulatory authorities, previous studies, large-scale adverse events initiatives: febrile seizure, aseptic. It's important to be aware of these reactions: Some rare serious reactions that have occurred after COVID-19 vaccines include: 7 Anaphylaxis Myocarditis Pericarditis Thrombosis with. Safety data on recombinant protein infusions are not available and the paucity of publications suggests little ongoing development. N Engl J Med. The immune system then creates antibodies against it which is controlled inflammation and can remember how to trigger an immune response if exposed to the virus in the future. Nurse researcher Kristen Choi, PhD, experienced first-hand a "worst-case scenario" of potential side effects after receiving an experimental COVID-19 vaccine in a phase III trial. UAB is an Equal Opportunity/Affirmative Action Employer committed to fostering a diverse, equitable and family-friendly environment in which all faculty and staff can excel and achieve work/life balance irrespective of race, national origin, age, genetic or family medical history, gender, faith, gender identity and expression as well as sexual orientation. 2020;80 Suppl 6:104-106. Vaccines (Basel). Use of the Janssen (Johnson & Johnson) COVID-19 vaccine: updated interim recommendations from the advisory committee on immunization practicesUnited States, December 2021. 2020;288:198114. This past year, more than 4,500 employees activated their My Health Rewards account, and more than 3,400 logged enough healthy behaviors to receive a payout of $50 or more. BMJ. Nausea was the most frequent adverse event, noted in 4 (3.6%) patients who received the combination and 6 (3.8%) who received saline. Fields virology: emerging viruses. Turn your October into WALKtober with Employee Wellness, What are the long-term side effects of COVID vaccines? For the Pfizer vaccine, myocarditis was most common during the 7days after the second Pfizer-BioNTech dose for males and females aged 1617, at 105.86 [95% CI, 91.65122.27] and 10.98 [95% CI, 7.1616.84] cases per million doses, respectively. Efficacy and safety of the RBD-dimer-based Covid-19 vaccine ZF2001 in adults. MMWR Morb Mortal Wkly Rep. 2021;70(2):4651. Up to 10 percent of people who have COVID experience side effects such as difficulty thinking, pain, tiredness, loss of taste and depression. ), More recently, an even more rare side effect myocarditis, or inflammation of the heart muscle has been reported in people receiving Pfizer and Moderna COVID-19 vaccines. 2021;384(3):22937. Tanriover MD, Doanay HL, Akova M, Gner HR, et al. Sputnik Light is the first dose of Sputnik V. It was created to facilitate distribution to countries with widespread infection that need to quickly vaccinate. Google Scholar. It was hoped that APN01 would prevent SARS-CoV-2 from entering the cell just as it did for the structurally similar SARS-CoV-1. MAbs. The action you just performed triggered the security solution. The mRNA is packaged into lipid nanoparticles (LNPs) and stabilized with polyethylene glycol. Kannemeier C, Shibamiya A, Nakazawa F, Trusheim H, et al. We dont know why that is, how long these symptoms will last or if there are effective ways to treat them. The CDC reports J&J/Janssen vaccine was 66.3% effective in clinical trials at preventing COVID-19 illness in people who had no evidence of prior infection 2 weeks after receiving the vaccine. University of Florida, 2018. Unauthorized use of these marks is strictly prohibited. Sotrovimab binds to a region in S2 that helps the host and virus membrane fuse. JAMA. The incidence of local reactions in the ZF2001 group was 18.8% and systemic reactions was 25.1%. There were 4 cases of Bells palsy in the vaccine group (and none in the placebo group or in the 5 to 11, 12 to 15 age groups), a frequency that is not greater than the baseline frequency in that population. In another trial, there were no serious adverse reactions reported, with the most common being pain at the injection site (7/110) and a flu-like symptom (72/110). 2022 Aug 17;17(8):e0272876. Developing covid19 vaccines at pandemic speed. Serious adverse events occurred in 103 of 295 patients (34.9%) in the tocilizumab group and in 55 of 143 patients (38.5%) in the placebo group. Burn E, Li X, Kostka K, Stewart HM, et al. Chinas CoronaVac and Sinopharm vaccines, used in China as well as 54 other countries, account for almost half of the 7.3 billion COVID-19 vaccine doses delivered globally [99]. PMID: 33483637 PMCID: . Between March and August 2021, 54 valid cases (out of 14,080,087 vaccination administrations) were reported, a case-event rate of 3.8 cases per million Johnson & Johnson COVID-19 vaccine doses. No children who received the combination therapy died or were hospitalized during treatment. Secondary Outcome Measures : 2000;355(9205):73540. The infusion had to be stopped in 3 because of urticaria, dyspnea, chest tightness, and vomiting. N Engl J Med. Zare H, Rezapour H, Mahmoodzadeh S, Fereidouni M. Prevalence of COVID-19 vaccines (Sputnik V, AZD-1222, and Covaxin) side effects among healthcare workers in Birjand city, Iran. FDA grants Dupixent (dupilumab) Breakthrough Therapy designation for To all vaccines we discuss, women are slightly more likely to have an anaphylactic reaction than men, but the absolute risk is small. Why vaccine side effects really happen, and when you should worry - Science Custers J, Kim D, Leyssen M, Gurwith M, et al. A semester-long series of free nutritional seminars, lunch-and-learns and cooking demonstrations is designed to help you eat and live well. Bamlanivimab/etesevimab and casirivimab/imdevimab bind to the receptor binding domain [15]. Cell Tissue Res. Extracellular RNA may impact endothelial processes [53], promoting coagulation [54, 55] and vascular permeability [56]. Covid-19 vaccine and immunosuppressive drugs. Rosas IO, Bru N, Waters M, Go RC, et al. Serious events were reported in 0.6% of patients in the vaccine group and 0.5% in the placebo group, most frequently appendicitis (7 vs 2 cases), acute myocardial infarction (3 vs 0 cases) and cerebrovascular accident (3 cases vs 1 case). ISSN 0007-0610 (print), https://doi.org/10.1038/s41415-021-2615-x, https://stars.library.ucf.edu/cgi/viewcontent.cgi?article=1306&context=honorstheses. Accessed 14 May 2022. of people receiving a COVID-19 vaccine for the first time experienced this side effect. Clin Infect Dis. "But because we have had so many people vaccinated, we actually have far more safety data than we have had for any other vaccine, and these COVID vaccines have an incredible safety track record. Most side effects occur within the first three days of vaccination and . Accessed 23 Mar 2022, U.S. Food and Drug Administration. In February 2021, the FDA issued an EUA for a one-time infusion of the combination of bamlanivimab 700mg and etesevimab 1400mg to treat COVID-19 in non-hospitalized adults and children at high risk for progression to severe disease [13]. CanSinBio is a DNA vaccine like Johnson & Johnson. J Virol. Yes, you can take OTC pain meds after getting the Covid vaccine, says CDC plus other tips for dealing with side effects. J Infect Dis. MeSH Myocarditis and pericarditis after immunization: gaining insights through the Vaccine Adverse Event Reporting System. Here is why, starting with the way vaccines work and continuing through strong evidence from vaccine history and the even stronger evidence from the responses of people who have received COVID-19 vaccines worldwide over the past six months. The CCL5/CCR5 axis promotes interleukin-6 production in human synovial fibroblasts. The patient improved after 2 doses of 0.3mg intramuscular epinephrine. She says . 2022;146(10):74354. Take a walk around campus to find a little-known green space closest to you and take a moment for mindfulness using this Google Map we created just for you. Adverse events affecting the orofacial region were reported for both vaccines. https://doi.org/10.1056/NEJMoa2104840. 2021;25(3):16631669. What are the vaccines' side effects? - Mayo Clinic - Mayo Clinic Binding to the RBD prevents SARS-CoV-2 from attaching to and then infecting human cells. Afrifa-Anane GF, Larbi RT, Addo B, Agyekum MW, Kyei-Arthur F, Appiah M, Agyemang CO, Sakada IG. https://doi.org/10.15585/mmwr.mm7035e5. Women reported more adverse events than men (P<0.001), more AEs occurred after the first dose than the second dose (P<0.001), and the number of AEs decreased with age (P<0.001). U.S. Food and Drug Administration. Rev Med Inst Mex Seguro Soc. 2005;385(Pt 3):8318. We don't know why that is, how long these symptoms will last or if there are effective ways to treat them. People who get a COVID-19 vaccine may feel pain, redness and swelling in the location of the shot, according to the CDC, adding that throughout the body people may feel fatigue, muscle pain, chills, fever, headaches and nausea. In 1976, a vaccine against swine flu that was widely distributed in the United States was identified in rare cases (approximately one in 100,000) as a cause of Guillain-Barr Syndrome, in which the immune system attacks the nerves.